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A Comparison of the Effects of Morphine and Sublingual Desmopressin Combination Therapy with Morphine Alone in Treatment of Renal Colic: A Controlled Clinical Trial

Maliheh Keshvari Shirvani, Mohammadreza Darabi Mahboub, Mahdi Ghazi, Alireza Delijani




Purpose: To compare the therapeutic efficacy of combined desmopressin and morphine with morphine and placebo on acute renal colic.

Materials and Methods: In a single blind case-control clinical trial 81 consecutive patients, 54 males and 27 females with the mean age of 30.12 ± 9.88 years, presenting with acute renal colic to the urology emergency unit were studied. The patients were randomly assigned into two groups. The 40 cases were treated with 0.1 mg/kg IM morphine and 60 μg of sublingual desmopressin melt; whereas the 41 controls received the same dose of morphine beside a placebo.

Results: There were no significant statistical differences regarding the mean age, gender, stone size, location and affected side between the two groups. Our results showed a significantly higher acuity of pain in the study group in comparison to the controls at 10, 20 and 30 minutes of receiving the medication (P = .06, .017 and P = .008, respectively).

Conclusion: No superiority was found in adding desmopressin to morphine compared to the traditional treatments (opioids only) in relieving the pain of acute renal colic cases.


DOI: http://dx.doi.org/10.22037/uj.v12i1.2065


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