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The Association between Serum Follicle-Stimulating Hormone Levels and the Success of Microdissection Testicular Sperm Extraction in Patients with Azoospermia

Mehmet Erol Yildirim, Akif Koc, Akif Koc, Ikbal Cekmen Kaygusuz, Ikbal Cekmen Kaygusuz, Hüseyin Badem, Huseyin Badem, Omer Faruk Karatas, Omer Faruk Karatas, Ersin Cimentepe, Ersin Cimentepe, Dogan Unal, Dogan Unal
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Abstract

Purpose: To evaluate the predictive power of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, testicular biopsy histology and male age were evaluated with respect to the success of sperm retrieval in a microdissection testicular sperm extraction (microTESE) procedure, pregnancy and live birth rates.

Materials and Methods: We examined the data of 131 infertile men with non-obstructive azoospermia, who have undergone microTESE operation. The men were classified into two groups based on serum follicle-stimulating hormone (FSH) levels ≤ 15 mIU/mL (group 1) and > 15 mIU/mL (group 2).

Results: Group 1 consisted of 59 patients (mean age 36.2 ± 6.2 years) and group 2 consisted of 72 (mean age 38.8 ± 7.4 years) patients. Sperm retrieval and pregnancy rates were 66.1% and 16.9% in normal FSH group, respectively. These parameters were higher than those of men with FSH > 15 (43% and 8.3%, respectively). Only 128 patients had histopathological diagnosis. Sperm was retrieved from 12/30 (40%) patients with maturation arrest, 9/29 (31.03%) patients with seminiferous tubules atrophy, 14/40 (35%) patients with sertoli cell only syndrome and 13/13 (100%) of patients with hypospermatogenesis. There was no statistically significant difference in pathological diagnosis between pregnancy and live birth rates.

Conclusion: These results demonstrate that there is a significant difference with sperm retrieval, preg­nancy rates and live birth rates comparing the FSH levels. Histopathological findings did not associate with successful microTESE, pregnancy rates and live birth rates.

 




DOI: http://dx.doi.org/10.22037/uj.v11i4.2536

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