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A Nonspecific Penile Ulcer Leading to the Diagnosis of Wagner’s Granulomatosis

Hassan Ahmadnia, Amin Hasanzadeh Haddad, Mohammad Reza Darabi Mahboub, Ali Akhavan, Ali Reza Akhavan Rezayat
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Abstract

The presented case concerns a 53-year-old male who had been treated for nonspecific cutaneous lesions for two months without any improvement. After developing an erosive penile ulcer he was referred to our department. Investigation for sexually transmitted diseases and Mycobacterium tuberculosis ended with negative results. A penile ulcer biopsy suggested the diagnosis of Wagner’s granulomatosis (WG). Patient during this period presented with upper respiratory tract symptoms. Measuring antineutrophil cytoplasmic antibodies (c-ANCA), confirmed the diagnosis. Immunosuppressive therapy was initiated and resulted a favorable response.


References

Reference:

Vella E, Waller D. Granulomatous vasculitis of the penis with glomerulonephritis. Postgraduate medical journal. 1981;57(666):262-4.

Al Rajabi W, Venturini M, Sala R, Calzavara-Pinton P. Wegener’s granulomatosis of the penis: genital presentation of systemic disease. Dermatology. 2006;212(4):370-2.

Stucker F, Masouyé I, Toutous-Trellu L. Fever and penis ulcer in an 87-year-old man. Dermatology. 2006;212(4):397-8.

Bories N, Becuwe C, Marcilly M, Wolf F, Balme B, Thomas L. Glans penis ulceration revealing Wegener’s granulomatosis. Dermatology. 2007;214(2):187-9.

Gomes GL, Halpern A, Souza F, Shinjo SK. Association between saddle nose deformity and retro-orbital mass in Wegener's granulomatosis. Acta reumatologica portuguesa. 2010;35(3):340-5.

Jayne D, Group EVS. Update on the European vasculitis study group trials. Current opinion in rheumatology. 2001;13(1):48-55.

Stegeman CA, Boomsma MM, Tervaert JWC. Trimethoprim-sulfamethoxazole monotherapy for active loco-regional or limited Wegener's granulomatosis. Anca Associated Vasculitis: Occurrence, Prediction, Prevention, And Outcome Of Relapses. 2001:107.

Stone JH. Limited versus severe Wegener's granulomatosis: baseline data on patients in the Wegener's granulomatosis etanercept trial. Arthritis & Rheumatology. 2003;48(8):2299-309.

Matsuda S, MITSUKAWA S, ISHII N, SHIRAI M. A case of Wegener's granulomatosis with necrosis of the penis. The Tohoku journal of experimental medicine. 1976;118(2):145-51.

Takeuchi H, Kuroda I, Takizawa I, Aoyagi T, Tachibana M. Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Accompanied by Dysuria. Case reports in urology. 2016;2016.

Francès C, Piette J-C, Saada V, Boisnic S, Wechsler B, Blétry O, et al. Wegener's granulomatosis: dermatological manifestations in 75 cases with clinicopathologic correlation. Archives of dermatology. 1994;130(7):861-7.

Davenport A, Downey S, Goel S, Maciver A. Wegener's granulomatosis involving the urogenital tract. BJU International. 1996;78(3):354-7.

Geffriaud-Ricouard C, Noe lLH,Chauveau D, et al. Clinical spectrum associated with ANCA of defined antigen specificities in 98 selected patients. ClinNephrol 1993; 39:125–36.

Lutalo PM, D'Cruz DP. Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis). Journal of autoimmunity. 2014;48:94-8.




DOI: http://dx.doi.org/10.22037/uj.v0i0.4526

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