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The role of Vitamin E – Selenium - Folic Acid Supplementation in Improving Sperm Parameters After Varicocelectomy: A Randomized Clinical Trial

Arash Ardestani Zadeh, Davood Arab, Naim Sadat Kia, Sajjad Heshmati, Seyed Nilofar Amirkhalili



Purpose: In this study, we aimed to evaluate the effects of antioxidants including Vitamin E-Selenium-Folic acid (Vit E -Se- FA) on semen parameters following varicocelectomy (VCT).

Materials and Methods: Sixty patients from 64 infertile male patients diagnosed with varicocele (VC) who un­derwent sub-inguinal VCT were included in the study. Following sub-inguinal VCT, the patients were randomized into two groups: 30 receiving Vit E-Se-FA supplementation for six months, and 30 as the control group with supplemental treatment. The post-operative semen parameters of Vit E-Se-FA receiving group were compared with control group at the end of experiment. The sperm count, percentage of motile and abnormal sperms were considered.

Results: There were statistically significant differences in terms of count (P = .031) and motility (P = .01) of sperm after six months of receiving Vit E-Se-FA supplementation comparing with control group.

Conclusion: Vit E-Se-FA supplementation can improve sperm parameters (count and motility of sperm) after VCT.

DOI: http://dx.doi.org/10.22037/uj.v0i0.4653


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